2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice.

نویسندگان

  • Owen J Bowers
  • Kirsa B Sommersted
  • Ryan T Sowell
  • Gretchen E Boling
  • William H Hanneman
  • Richard G Titus
  • Gregory K Dekrey
چکیده

Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major-infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.

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عنوان ژورنال:
  • The American journal of tropical medicine and hygiene

دوره 75 4  شماره 

صفحات  -

تاریخ انتشار 2006